The Dietary Science Foundation
Telephone:+46 70-750 22 16
269 39 Båstad
Abdominal obesity, prediabetes, and type 2 diabetes carry an increased risk for cancer. One likely explanation for the risk increase is that high insulin levels in the blood trigger the body’s growth system. Theoretically, a diet that lowers insulin levels could help more people survive their cancer. The Dietary Science Foundation wants to investigate this through well-constructed scientific studies.
Someone who has abdominal fat, prediabetes or type 2 diabetes can have ten times more insulin in their blood after a meal than a healthy person. Insulin not only lowers blood sugar but also stimulates cell growth. In addition, insulin activates another important growth factor in the body: IGF-1. Most cancer cells have receptors for both insulin and IGF-1 on their surfaces. When growth factors attach to these receptors, the cells are given a signal that they should grow.
This biochemical mechanism may explain why people with abdominal fat, prediabetes and type 2 diabetes have a higher risk of getting certain kinds of cancer, and why it’s often a more aggressive form.
There are studies that suggest that dietary glycemic index might affect the development of cancer, but they are too few and too small. The research needs to be strengthened. If you want to support our fight against cancer, please join us as a one-time or monthly donor. In this way, you help us in our long-term efforts.
Metabolic Dysregulation of the Insulin–Glucose Axis and Risk of Obesity-Related Cancers in the Framingham Heart Study-Offspring Cohort (1971–2008)
Prediabetes and the risk of cancer: a meta-analysis
Longitudinal associations of blood markers of insulin and glucose metabolism and cancer mortality in the third National Health and Nutrition Examination Survey
Therapy insight: Influence of type 2 diabetes on the development, treatment and outcomes of cancer
Blood glucose and risk of incident and fatal cancer in the metabolic syndrome and cancer project (megan): analysis of six prospective cohorts
Fasting insulin and outcome in early-stage breast cancer: results of a prospective cohort study
Fasting serum glucose level and cancer risk in Korean men and women
Glucose as a prognostic factor in ovarian carcinoma
Glucose as a prognostic factor in non-diabetic women with locally advanced cervical cancer
Insulin, the insulin-like growth factor axis, and mortality in patients with nonmetastatic colorectal cancer
Impact of consumption of vegetable, fruit, grain, and high glycemic index foods on aggressive prostate cancer risk